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Dr. Yu-Dong Zhou's Group Uncover a Developmental Role of Astrocytes in Promoting Synapse Generation(Journal of Cell Biology)

2016-11-25   |  

Prof. Yu-Dong Zhou, a principal investigator in the Institute of Neuroscience, and his colleagues demonstrate a developmental role of astrocytes in shaping a predisposition to seizure generation. Activation of TLR4-MyD88-ERK1/2 signaling pathway in astrocytes during a critical postnatal period promotes excitatory synapse generation, leading to enhanced seizure susceptibility.The results were published in The Journal Cell Biology on November 10, 2016 (DOI: 10.1083/jcb.201605046).